Research News
July 01, 2007
TDP-43 protein's absence may mean SOD1 ALS is different
ALS that stems from mutations in the SOD1 gene may be biochemically different from ALS from other causes, suggests a report published in the
June 26, 2007
A study in the May 29 issue of Neurology is the third to find that a viral protein known as reverse transcriptase is more frequently found in the blood of people with amyotrophic lateral sclerosis (
June 01, 2007
The hallmark of ALS is the degeneration of two kinds of motor neurons — upper, which are in the brain, and lower, which are in the anterior horn (front section) of the spinal cord and in the
June 01, 2007
‘Toxic neighbors’ likely kill nerve cells, at least in SOD1-caused ALS
Nervous system support cells known as astrocytes and nervous system immune cells called microglia appear to play a role in
May 01, 2007
Research progress in spinal muscular atrophy (SMA) has been considerable in recent months.
Some 95 percent of people with this disorder of the muscle-controlling nerve cells of the spinal cord (
May 01, 2007
Date
Trial or Study
Benefits
Side Effects
1970s-1980s
4 trials used prednisone in high doses ranging from 1.5 mg/kg/day to 5 mg/kg on alternate days
prolongation of walking by about 2 years in one
May 01, 2007
Caregivers may be more discouraged than people with ALS
A study conducted at the University of Torino in Italy has found that when 31 people with ALS and
May 01, 2007
The year since May 2006 has witnessed several steps in the evolution of ALS research. Results aren’t yet available for several causative factor and treatment studies, but in many cases, they’re
April 01, 2007
NIH group finds no clear DNA clues to ALS
No significant genetic differences were found in a recent study of 276 people with sporadic (nonfamilial) ALS and 271 without the disease, says a report
April 01, 2007
Steven Perrin, recently named chief scientific officer of the ALS Therapy Development Institute (ALS TDI) in Cambridge, Mass., didn’t start out to be a scientist, although his interest in science
March 01, 2007
In 1990, Sara Winokur was a doctoral student in the laboratory of John Wasmuth, a professor of biological chemistry and a prominent researcher in genetics at the University of California at Irvine.
February 01, 2007
When good cells go bad, as they seem to do in ALS, you have to ask the same questions distraught parents sometimes ask about wayward children: Is the problem strictly internal? Are outside influences
January 01, 2007
On Nov. 30, scientists from the Translational Genomics Research Institute (TGen) in Phoenix
January 01, 2007
Editor’s Note: The 17th International Symposium on ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neurone Disease), held in Yokohama, Japan, Nov. 30 through Dec. 2, showcased important research
![[title]](http://alsn.mda.org/files/alsn/imagecache/175xFrontFeature/11-7%20cover%20story%20art.jpg)
August 01, 2006
"When I saw the first set of data in March of last year, I immediately sat up,” says neuroscientist Denise Figlewicz, an MDA-supported ALS researcher at the University of Michigan in Ann Arbor.
April 01, 2006
Angiogenin mutations likely boost ALS susceptibility
Mutations in the gene for angiogenin (ANG), a protein that aids in the formation of new blood vessels, are
April 01, 2006
(above) Alana Lysholm-Bernacchi is working at the gene chip fluidics station.
(below) Sarah Brautigam works at TGen's gene chip hybridization ovens. Photos by David Pantoja
At 36, Dietrich
![[title]](http://quest.mda.org/sites/default/files/imagecache/mda_org_frontpage100x75/DNA%20syringe%202.JPG)
March 29, 2006
The first U.S. human gene therapy trial directed at Duchenne muscular dystrophy (DMD) was launched yesterday at Columbus (Ohio) Children's Hospital, the Muscular Dystrophy Association (MDA), Children
![[title]](http://quest.mda.org/sites/default/files/imagecache/mda_org_frontpage100x75/Bonneman_Keener_13-1.jpg)
January 01, 2006
Just a few years ago, almost nothing could be said to parents like those in “Families Left with Questions,” other than that their child had a congenital (present at or near birth) form of muscular
September 01, 2005
Depression doesn't dominate in ALS
Only 15 (19 percent) of 80 people with late-stage ALS recently surveyed met standard criteria for a diagnosis of depression, say investigators at the Eleanor and
July 06, 2005
Long-ago residence on Guam is likely ALS risk factor
In a study that included 140 people with ALS and another 140 without the disease, those with ALS were found to be eight times more likely to have
July 06, 2005
The first real break in solving the mystery of ALS causation came in 1993, when MDA-supported investigators linked one form of familial
July 01, 2005
Learning about advances in the search for a cure to neuromuscular diseases using gene therapy is exciting. And even though I’ll be very happy when
April 03, 2005
Embryonic stem cells can become motor neurons
Researchers at the University of Wisconsin-Madison announced online on Jan. 30, in Nature Biotechnology, that they’ve developed a chemical recipe to coax
March 01, 2005
In this article: research news about prednisone in Duchenne MD; tests for Duchenne and Becker MDs; and the latest progress in research for spinal muscular atrophy
Offer prednisone for DMD, neurology
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