Research News
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January 01, 2009
Mia Hanley of Cranston, R.I., looks pretty much like any 4-year-old preschooler. She’s a normal height and weight, walks well and has good language skills. In fact, when she started preschool at age
January 01, 2009
Genes encased in adeno-associated virus (AAV) delivery vehicles are injected into muscle. From there they can travel through the nerve fiber to the nervous system.
In a recently completed clinical
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January 01, 2009
On Nov. 17, the Research Advisory Committee on Gulf War Veterans’ Illnesses released a 454-page report linking exposure to nervous-system toxins with the development of illness in Gulf War veterans
January 01, 2009
Stem cells injected into spinal cord slow ALS progression in rats
Nicholas Maragakis led a research team
December 01, 2008
Stem cells entered nervous system but didn’t slow ALS
Although six men with ALS who received intravenous infusions (“transplantations”) of donated bone marrow stem cells failed to derive any apparent
October 01, 2008
Scientists create nerve cells from skin cells of woman with ALS
MDA grantee Hiroshi Mitsumoto at Columbia University was on the study team that created nerve cells from skin cells.
MDA-supported
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July 01, 2008
What do inflammatory muscle diseases (myositis), myasthenia gravis, Lambert-Eaton syndrome, and dozens of other disorders like lupus and rheumatoid arthritis, have in common?
In all these and more,
July 01, 2008
When Jerry DeZutter first came to the ALS Therapy Development Institute in 2005, meetings focused on “frank and open discussions about the life of the institute — whether it would survive,” he says
July 01, 2008
Gene therapy experts discuss targeting ALS-affected cells
The 11th annual meeting of the American Society of Gene Therapy (ASGT) took place in Boston May 28-June 1. Among the dozens of sessions was
June 01, 2008
MDA-funded lithium trial is now open
The MDA-funded trial is designed so that all participants will receive lithium.
Neurologist Robert Miller, director of the Forbes Norris MDA/ALS Research Center
May 01, 2008
The road to ALS treatment development has been long and hard. But MDA, along with the National Institutes of Health (NIH) and pharmaceutical companies, is finding there are more frequent signposts.
May 01, 2008
Does a high serum cholesterol level increase survival time in ALS?
A French research team that published its findings March 25 in Neurology has found that elevated levels of lipids (fatlike
April 01, 2008
FDA confirms rat study results are reason for arimoclomol trial hold
According to a Feb. 11 press release from CytRx, developer of arimoclomol, the company has received written correspondence from
March 01, 2008
MDA to fast-track lithium trial
A small trial has suggested that lithium carbonate may dramatically slow ALS progression. Larger trials will be needed to confirm these results.
An MDA-supported
March 01, 2008
A European group of researchers successfully used a combination of genetic correction and stem cells to treat Duchenne muscular dystrophy (DMD) in mice with the disease. The compound they used for
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February 01, 2008
CytRx to test arimoclomol at higher dose
Merit Cudkowicz at Massachusetts General Hospital is one of the principal investigators for the arimoclomol trial.
Editor's note: On Jan. 22, CytRx
January 01, 2008
ALS specialists discuss clinical trial results, methods at Toronto conference
Some 750 conferees, mostly ALS clinical and scientific experts, gathered in Toronto Dec. 1-3 for the 18th International
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November 01, 2007
When Rena Szymanski turned 40, she expected to slow down a bit. She never had been athletic, and it sometimes seemed to her that climbing stairs was harder for her than it was for other people, but
November 01, 2007
New studies strongly support ALS-angiogenin connection
A study conducted by investigators at several institutions in Boston has added additional support to an existing hypothesis based on earlier
October 01, 2007
In January, MDA announced a new strategic partnership with the ALS Therapy Development Institute in Cambridge, Mass., to identify molecular targets for drug development and to screen potential
October 01, 2007
Emotional-control drug development to move forward, Avanir says
The experimental drug Zenvia is designed to
September 01, 2007
Diseased featured in this article include: Duchenne muscular dystrophy, Friedreich's ataxia and myotonic musuclar dystrophy.
ID of utrophin brake raises DMD treatment hopes
MDA-supported researchers
September 01, 2007
ALS-statin interactions probed
A report this summer from the World Health Organization (WHO) Collaborating Centre for International Drug Monitoring caused a stir by suggesting that widely
September 01, 2007
Failure to recognize differences among mice with mutated SOD1 genes may be the key to understanding why so many medications that looked good in mouse studies later failed to benefit humans with
July 01, 2007
The announcement this spring that yet another promising drug had failed to help people with ALS in a clinical trial has led some in the field to re-examine some assumptions.
Minocycline, an
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