FRG1 May Affect ‘Final Version’ of Genes

Researchers at Leiden University in the Netherlands have added to existing knowledge about the FRG1 protein, which is made from a gene strongly implicated in facioscapulohumeral MD (FSHD) by some prominent investigators.

Silvana van Koningsbruggen and colleagues, including MDA-funded Silvere van der Maarel, say their experiments demonstrate the probable role of FRG1 in RNA splicing, a cellular process that takes “rough draft” genetic instructions to their final version.

Their paper, published in the February issue of Chromosoma, reports identification of several splicing-related proteins associated with FRG1.