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Quest publishes articles on all aspects of living with a neuromuscular disease, and updates on research findings. Quest’s circulation is 125,000.


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  Home> Publications > QUEST >QUEST Vol 5 No 4 August 1998
SPOTLIGHT ON GENE THERAPY AND MUSCLE
MD Human Trials will Target Membrane

Article Illustration:

Diagram: Targeting the Membrane

When dystrophin (dark blue) is missing or diminished, Duchenne or Becker MD results. Loss of any of the sarcoglycans (yellow) leads to a limb-girdle type of MD. When laminin-2 (green) is lost, a disorder results that's known as congenital MD. The small adeno-associated virus can be sued to deliver genes for the sarcoglycans, while the larger adenovirus will be needed to transport genes for dystrophin or laminin-2.

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